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Environmental Health Science Laboratory

Mutagenicity test (Ames test)

This laboratory evaluates the possible impact of chemical substances on human health and the environment using the latest scientific knowledge as well as state-of-the-art technologies.
The laboratory aims to further enhance the company’s life science and other businesses and accelerate research and development by conducting basic and applied research relating to ES and iPS cells and safety assessment research using omics technologies by cooperation with the Bioscience Research Laboratory.

Major Research Areas

Human and environmental exposure assessment of chemical substances

Crop residue trial in oversea field(application of agrochemical)

The precise estimation of human and environmental exposure to chemical substances with various usage scenarios is indispensable for their safety assessment. The laboratory is fully committed to the environment risk assessment of our products by utilizing high-precision data from field measurement and computer simulation to elucidate their environmental behavior.

Safety assessment research using ES and iPS cells

ES *1 and iPS*2 cells are able to proliferate indefinitely and differentiate into various cell types in the adult body when given the correct stimulation in a culture dish. Our lab conducts basic research using ES and iPS cells to develop novel alternative methods to reduce the number of animal experiments and for elaborate assessments of the safety (toxicity) and efficacy of chemicals in humans.

  • *1 ES cells: Embryonic Stem Cells
  • *2 iPS cells: induced Pluripotent Stem Cells (artificially derived from non-pluripotent cells)
  • 1.Human ES cells (KhES-1 line, established at Kyoto University; phase contrast image)
  • 2.Neural cells derived from human ES cells (immunofluorescence image)
  • 3.Retinal pigment epithelium derived from human ES cells (phase contrast image)
  • 4.Retinal pigment epithelium derived from human ES cells (immunofluorescence image)

Development of in silico predictive technology for chemical safety assessment

Computational Safety Assessment Research

In silico predictive technology is necessary to assess safety of numerous chemicals including newly developed ones promptly and precisely. We are working on development of predictive technologies for toxicokinetics and chemical safety assessment based on mechanisms of toxicity. These technologies are important in assessing products of Sumitomo Chemical.