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R&D Reports

vol. 1995 - II (1996.1.31 issue)

Advancement of Optical Films for LCD

The remarkable growth of Liquid Crystal Display (LCD) market is owing to the improvement of its performance and the creation of new markets. Since a start in business of the retardation film "Sumikalight®" and the polarizing film "Sumikalan®", to improve the performance of LCDs, these optical films have been advanced in many points such as polarization properties, surface properties, viewing angle characteristics, etc.
In this paper the advancement of these films is described.
( by Fumio FUJITA, Kazuaki SAKAKURA, Yukio YASUNORI, Nobuyuki KURATA, Kohji HIGASHI, Toshihiro OHNISHI, Kazuya OGINO )

Construction of Recombinant Yeast Strains Expressing Human Cytochromes P450 and Their Application for Drug Metabolism Studies

Cytochrome P450 represents a large group of hemoproteins that catalyze the oxidation of a wide variety of both endogenous and exogenous compounds. Recent advances in molecular biology have revealed the multiplicity of P450 at the molecular level. In addition, genetic engineering enables the expression of mammalian P450 species including human ones in heterologous hosts such as yeast and bacteria. We have established a yeast expression system for mammalian P450 and have constructed recombinant yeast strains expressing each of major eleven P450 species from human liver. These series of recombinant yeast strains are useful for in vitro prediction of metabolism of new chemical compounds, especially for the identification of the P450 species responsible for the metabolism and for analysis of the major matabolites in human.
( by Yoshiyasu YABUSAKI, Megumi AKIYOSHI, Koji HAYASHI )

Ethylene-Vinylacetate Copolymer Emulsion - Sumikaflex® -

Sumikaflex® has wide range of product lines such as ethylene-vinylacetate copolymer emulsion, ethylene-vinylacetate-vinylchloride copolymer emulsion and ethylene-vinylacetate-acrylate copolymer emulsion.
Sumikaflex® is applied for adhesive, construction (Ex. mortar mixing), paper (Ex. impregnation) and textile (Ex. binder for non-woven fablic).
In this paper, first we briefly present the basic design of ethylene copolymer emulsion and then we introduce some new grades which are suitable for adhesives and paper-textile.
( by Yuji YOSHII, Choji TOMIZAWA, Tatsuo MITSUTAKE )

SR-SAXS Study of Deformation Mechanisms of PPE Alloys

PPE(poly phenylene ether) is one of ductile polymers, and possesses high glass transition temperature. For the improvement of heat resistance, several PPE alloys have been developed. In this paper, toughening mechanisms of PPE alloys are investigated concerning following items by means of SR-SAXS(Synchrotron Radiation Small-Angle X-ray Scattering).
The effect of rubber properties on the deformation processes of PPE/polyamide alloys.
The effect of PPE content on the deformation processes of PPE/PS alloys having bimodal rubber particle distribution.
( by Yasuhito IJICHI, Yuji SAGA, Takeshi FUJII, Keisaku YAMAMOTO )

Novel Thermoplastic Elastomer Through New Graft Copolymerization

We have succeeded in developing the novel thermoplastic elastomer (TPE) having both softness and higher heat resistivity as compared with those reported so far, by way of the graft copolymerization of rigid rod like oligomer derived from p-hydroxy benzoic acid to ethylene-methylacrylate-glycidyl methacrylate terpolymer.
( by Masahiro NIWANO, Kenji MANABE, Ichiki MURASE )

Responsible Care in Sumitomo Chemical

This articles describes Sumitomo Chemical's Responsible Care activities such as organization in charge, preparation of standards and rules, internal audit, and preparation of safety and maintenance control guideline as well as the activities in Process & Production Technology Center and Environmental Health Science Laboratory which play a supporting role, together with brief explanation of development and current situation of Responsible Care Activities in Japan.
( by Tadatsune FUKUNAGA )

Significance of Mechanistic Study of Toxicity

The objective of toxicological studies of chemicals (pesticides, pharmaceuticals, etc) using experimental animals is to extrapolate toxicity in human from that in the animals. However, it is well-known that there is a great species difference in toxicity of chemicals. Therefore, it is important to conduct mechanistic studies for better assessment of the toxicity in human.
In this paper, we introduce the recent results of our studies, and document the significance of the mechanistic study of toxicity and the future of this field.
( by Koichi SAITO, Yoshitaka TOMIGAHARA, Kunio SHIBA, Hideo KANEKO, Iwao NAKATSUKA )

The Methods of Technology Development for Production System -The Automation of Chemical Plants and Manufacturing Processes-

Recently, the environment of production system has been changed by the borderlss (economy) and the increasing variations of sense of values.
In this paper, to cope with the environment changes around companies and the technology revolution, we introduce the manufacturing technology group??s activities related to the automation of chemical plants and the technology development of the manufacturing processes with some examples.
In the field of chemical plants automation, the approaches for the development of the operator oriented production system by removing 3K operations (Kitanai ; Dirty, Kitsui ; Hard, Kiken ; Dangerous) are reported.
On the other hand, in the field of the manufacturing processes, the required technologies and the methods are explained.
( by Toshimasa NAKAI, Takayuki YAMAGUCHI, Osamu HIROSE, Takashi SUZUKI )

How to Promote Research and Development by Utilizing Databases -Information Retrieval as a Support of Research in Organic Synthesis.-

Information retrieval and analysis is becoming more and more important in R & D recently. We are emphasizing usage and application of various databases in order to promote R & D in organic synthesis.
In this article, present status of online databases and in-house databases are described and examples of applying various databases to R & D are introduced. Finally, future view of online and in-house databases are discussed.
( by Yoshikazu EMOTO, Kenji YOSHIMORI, Noriko OKA, Kumiko TANII, Mika KATAOKA, Hiroshi SATO )

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