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R&D Reports

vol. 2008 - II (2008.11.28 issue)

Development of a Novel Formulation: Pluto® MC to Control Mulberry Scale on Tea

Pluto® MC is a new concept insecticide which was developed by Sumitomo Chemical Co., Ltd to control mulberry scale on tea during winter dormancy (from January to March). This formulation is a self-burst type of micro capsule formulation containing 9% of pyriproxyfen to reduce the risk of drift when it is sprayed in the tea field. Dormant spray of this formulation can show good control efficacy against the mulberry scale for a long-term period and can greatly reduce the risk of toxicity to the silkworm at the same time. Also, it is promising for farmers as a new labor-saving technique. Moreover, this insecticide is suitable for integrated pest management (IPM) programs. In this report, the development of Pluto® MC is described focusing on its basic performance against the mulberry scale, formulation design, optimum application timing and efficacies.
( 4~13 by Shinji ISAYAMA,Naoki TSUDA )

Process Development of a Key Building Block for Anti-AIDS Drugs by Organocatalyzed Enantioselective Direct Cross-Aldol Reaction

We have been trying to apply environmentally benign organocatalysts to the synthesis of various kinds of pharmaceutical compounds. We herein report a practical synthesis of (3R,3aS,6aR)-hexahydrofuro[2,3-b] furan-3-ol (BFOL), a key building block for HIV protease inhibitors. The route is based on an enantioselective proline catalyzed direct cross-aldol reaction between aldehydes.
( 14~22 by Tetsuya IKEMOTO,Yosuke WATANABE )

Precision Synthesis of Aromatic Polymers Controlled by Transition Metal Complex Catalyst

Oxidative polymerization of phenolic monomers and cross coupling polymerization of asymmetrically functionalized monomers are described as the precession synthesis for aromatic polymers controlled by transition metal catalysts. New methodologies, namely radical-controlled oxidative polymerization of phenols with high regioselectivity and asymmetric oxidative coupling polymerization of naphthol derivatives with high stereoselectivity have been developed. For Kumada-Tamao type and Suzuki-Miyaura type cross coupling polymerization, not only the head-to-tail selectivity has been regulated, but also catalyst transfer polycondensation has converted polymerization growth mechanism from stepwise growth type into chain growth type.
( 22~38 by Hideyuki HIGASHIMURA,Masaaki KUBOTA,Kazuei OOUCHI,Daisuke FUKUSHIMA,Kenta TANAKA )

Structure Determination of Bicalutamide Polymorphic Forms by Powder X-ray Diffraction: Case Studies Using Density Functional Theory Calculation and Rietveld Refinement

Structure determination from powder X-ray diffraction data (SDPD) has been developing dramatically. A large amount of SDPD work is reported in the field of crystallography and material science. However, SDPD is not easier than that from single crystal X-ray diffraction data due to intrinsic overlap reflections in powder XRD data. In this report, SDPD of Bicalutamide form-I and form-II is performed by the Rietveld refinement in combination with density functional theory (DFT) calculations. The effectiveness of the DFT optimization for SDPD is discussed.
( 39~47 by Masamichi INUI,Masafumi UEDA )

Investigation of Synthetic Polymer Characterization by means of SEC/ESIMS

It is difficult to analyze synthetic polymers using mass spectrometry, because they have a very wide molecular distribution (Mw/Mn). But if we select a relatively low molecular species, we can obtain information on polymer structure by means of MS. In this paper we describe an analysis method for synthetic polymers by means of SEC/ESIMS (using q-MS), some analysis cases, and the problems of this method.
( 48~56 by Yoshinobu TSUCHIDA,Keiko YAMAMOTO,Hiromi YAMADA )

New Training in Safety for Core Engineers in Sumitomo Chemical

FE (Fire & Explosion) Training has been carried out as a new practical training course for all core engineers at Sumitomo Chemical since January 2007. It aims to develop the engineers’ knowledge of safety and disaster prevention, and sensitivity to danger in the chemical industry so that they can complete safe and stable operations in all factories and safe work in all laboratories. The training curriculum makes them safely experienced the danger of fire and explosions. Every trainee will gain sure and practical knowledge supported by the experience.
( 57~63 by Shinobu MARUNO )

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