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1. Asymmetric Organocatalysis Technology

What is an Organocatalyst ?

Organocatalysts are purely organic molecules composed of carbon, hydrogen, nitrogen, sulfur, and phosphorus. It can function as efficient and selective catalysts for a large variety of stereoselective transformation.

Berkessel, A.; Gröger, H. Asymmetric Organocatalysis: From Biomimetic Concepts to Applications in Asymmetric Synthesis; Wiley-VCH: Weinheim, 2005

Organometallic catalysts Organocatalysts
Types of organocatalysis

Thiourea Catalyst
Sumitomo Chemical’s Thiourea catalyst (Takemoto’s thiourea)
  • is a novel organocatalyst invented by Prof. Takemoto (Kyoto Univ.).
  • catalyzes various nucleophilic reactions such as asymmetric Michael addition and aza-Henry reaction with excellent enantioselectivity.
  • has already confirmed its effectiveness with wide variety of substrates at Sumitomo Chemical’s laboratory.
  • offers an excellent alternative to the synthesis of chiral gamma-amino acids and diamines and alpha amino acids.
Application to Drug Synthesis

Asymmetric Direct Aldol Reaction

  • After this pioneering work, a special team at the Health & Crop Sciences Research Laboratory of Sumitomo Chemical is extensively studying direct aldol reactions catalyzed by organcatalysts.
  • This simple but powerful method can offer a short cut to the installation of a chiral center in your development molecules.
  • Sumitomo Chemical can offer a reliable development process for the application of organocatalysis to your compounds.

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