A Challenge to the Chemical Synthesis of Ultra-Long RNAs up to 200 mer

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• This document introduces Sumitomo's advancements in synthesizing ultra-long RNAs, essential for fields like genome editing and Prime Editing. The innovation leverages PMM amidites with high coupling efficiency along with ZEO, a silica-based support optimized for long RNAs. These enable the efficient production of RNAs up to 200 mer. Additionally, Sumitomo advances measurement accuracy with high-resolution HPLC, which allows precise purity evaluation, even distinguishing single-nucleotide variations. These technologies position Sumitomo as a leader in oligonucleotide synthesis, contributing significantly to biotechnological and medical research.