Demonstration of Practical Direct Chemical Synthesis of RNA with 250 nucleotides

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• The document highlights further advancements in RNA synthesis, focusing particularly on the challenge of producing longer RNA sequences. Building on previous efforts, it describes progress in synthesizing RNAs of up to 250mer, surpassing earlier milestones of around 200 nucleotides. Key technological innovations include the use of high-efficiency amidites with compact protective groups and solid-phase supports featuring optimal pore sizes. Furthermore, the technology excels in producing long RNAs with a variety of chemical modifications, demonstrating its versatility and adaptability to meet diverse scientific needs.