R&D Reports

FY 2013

2013.7.31 issue

In recent years, the use of liquid crystal displays (LCD) has shown a great expansion into devices such as Smartphones and tablet PCs in addition to TVs and computer monitors. However, LCDs have issues such as low aperture ratio as a consequence of their high-definition and insufficient battery capacity. Improving the brightness of the color filter is expected to become one of the solutions for these issues. We have launched the DyBright® series of color photoresists which contains novel dyes, and which can contribute to improving the brightness of color filters. This report introduces the development of these novel dyes for color photoresists.
(4-9 by Masato INOUE, Toru ASHIDA)

High purity aluminium is widely used in electronics applications such as electrolytic capacitor foils, hard disk substrates, wiring materials in semiconductors utilizing its controllability of oxide layer and its absence of impurities or inclusions. It is also used as an electrical and thermal conductor for superconducting magnets at low temperatures. Here the recent progress in refining technologies for high purity aluminium and its physical properties and applications at low temperatures are shown.
(10-19 by Hiroaki HOSHIKAWA, Ichiro TANAKA, Tomohiro MEGUMI)

Recently, the demand for large storage batteries for electricity supply has been increasing remarkably. We have been developing a sodium ion secondary battery which has large storage capacity and which can work at ambient temperature without using rare elements.
In this paper, we introduce the trends in the development of the anode and cathode materials for sodium ion secondary batteries. Moreover we report on the electrical and safety properties of the sodium ion secondary batteries which contain our anode and cathode materials.
(20-30 by Satoru KUZE, Jun-ichi KAGEURA, Shingo MATSUMOTO, Tetsuri NAKAYAMA, Masami MAKIDERA, Maiko SAKA, Takitaro YAMAGUCHI, Taketsugu YAMAMOTO, Kenji NAKANE)

This paper presents an advanced technology for visual inspection of film products. Usually, a line sensor is used to inspect defects in web-shape products such as long films. However, one-dimensional image data captured via line sensors always includes restrictive optical information about defects. Therefore, inspection performance is limited. With the advantage of using area sensors, two-dimensional images containing more optical information can be obtained. The authors have established a novel imaging procedure which is based on two-dimensional motion images. The experimental results show that the new image processing framework enhances the appearance of defects. The authors also achieved an in-line web inspection system for film manufacturing lines.
(31-42 by Osamu HIROSE, Maya OZAKI)

In recent decades, quantum chemistry calculations have been used for various chemical fields such as reaction pathway analysis and spectroscopic assignments due to the theoretical developments, especially accuracy improvement of functionals in density functional theory (DFT), and high-speed parallel computers. However, the functionals in DFT should be appropriately employed for a target system or phenomenon because its reproducibility depends on the functionals used. Therefore comparison among obtained results with available experimental data or high-level computations is necessary to avoid misleading. In this review, we report the DFT-based mechanistic studies and spectroscopic analyses on reaction intermediates of catalytic reactions.
(43-52 by Akio TANAKA, Kensuke MAEKAWA, Kimichi SUZUKI)

Lurasidone hydrochloride received approval by the FDA in 2010 for the treatment of schizophrenia. Lurasidone is a full antagonist at dopamine D2 and serotonin 5-HT2A receptors, properties shared by most second-generation antipsychotics. Lurasidone also has high affinity for serotonin 5-HT7 and is a partial agonist at 5-HT1A receptors; it is believed that these properties could be potentially related to effects on cognition and mood.
Of particular note is that lurasidone has minimal affinities for receptors that might induce adverse events. The low affinity for alpha-1 noradrenergic receptors predicts a lower risk for orthostatic hypotension. Moreover the minimal affinity for 5-HT2C receptors and histamine H1 receptors predicts lower liability for weight gain as well. The lack of affinity for cholinergic M1 receptors predicts a low propensity for anticholinergic side effects. Our attempts to reduce adverse events had enabled us to obtain lurasidone with better tolerability and efficacy. Here, we report the synthesis, structure and activity relationships and pharmacological profiles of lurasidone.
(53-62 by Megumi MARUYAMA, Tomoko HORISAWA)

AIMIX® combination tablets LD&HD is a novel fixed-dose combination medicine of irbesartan, an angiotensin receptor blocker (ARB), and amlodipine besilate, a calcium channel blocker (CCB). This product was launched for the treatment of hypertension in Japan on Dec 19, 2012. In this review, we firstly outline the trends in antihypertensive drugs in the past decades and the current situation for combination tablets. We secondly review the development concept, pharmacological effects, and results of clinical trials of AIMIX® combination tablets LD&HD.
(63-69 by Masaya MORI, Hiroshi KATO)